New insights into the nutritional genomics of adult-onset riboflavin-responsive diseases

New insights into the nutritional genomics of adult-onset riboflavin-responsive diseases

Blog Article

Abstract Riboflavin, or vitamin B2, is an essential nutrient that serves as a precursor to flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN).The binding of the FAD and/or FMN cofactors to flavoproteins is critical for regulating their assembly and activity.There are over 90 proteins in the human flavoproteome that natio celebrate eyeshadow palette regulate a diverse array of biochemical pathways including mitochondrial metabolism, riboflavin transport, ubiquinone and FAD synthesis, antioxidant signalling, one-carbon metabolism, nitric oxide signalling and peroxisome oxidative metabolism.The identification of patients with genetic variants in flavoprotein genes that lead to adult-onset pathologies remains a major diagnostic challenge.

However, once identified, many patients with adult-onset inborn errors of metabolism demonstrate remarkable responses to riboflavin therapy.We review the structure:function relationships of mutant flavoproteins and propose new mechanistic insights into adult-onset riboflavin-responsive pathologies and metabolic dysregulations that apply to multiple biochemical pathways.We further address the vexing issue of how the inheritance of genetic variants in flavoprotein genes leads to an adult-onset disease with complex symptomologies and varying severities.We also propose a broad clinical framework that may not only improve the current diagnostic rates, but also facilitate a personalized approach popularfilm.blog to riboflavin therapy that is low cost, safe and lead to transformative outcomes in many patients.